Y: The Last Man is a critically acclaimed post-apocalyptic science fiction comic book series written by Brian K. Vaughan and illustrated primarily by Pia Guerra. Published by DC Comics under its Vertigo imprint, the series ran for sixty issues from 2002 to 2008. The story is set in a world where a mysterious plague has instantly killed every mammal with a Y chromosome, except for an amateur escape artist named Yorick Brown and his male Capuchin monkey, Ampersand.
The narrative follows Yorick as he travels across a devastated world, protected by a secret agent known only as Agent 355, and pursued by various factions with different agendas. These include the radical feminist group Daughters of the Amazon and Yorick's own sister, Hero. Meanwhile, Yorick's mother becomes the President of the United States, struggling to hold the country together. The series explores themes of gender, survival, and societal reconstruction.
Y: The Last Man was widely praised for its intelligent writing, complex characters, and thought-provoking exploration of a world without men. It won three Eisner Awards, including Best Writer for Vaughan and Best Penciller/Inker for Guerra. The series has been collected in multiple formats, including ten trade paperback volumes and five deluxe hardcover editions, and is considered one of the defining comic book series of the 2000s.